To raise money for cancer awareness, Mike Strange started the Box Run. He began running from Thunder Bay, Ontario towards Victoria, British Columbia on April 12, 2012. He ran 81 days of an average of over 40 km per day finishing his run on July 3, 2012 in Victoria at Mile Zero, 3149 km later.The Box Run raised over $100,000 dollars for Childhood Cancer Canada and Mike continues to raise awareness and funds for the same organization and is currently doing motivational talks to both children and adults at www.boxrun.org. On May 8,2014, Mike started another run for childhood cancer, this time he ran 94 Marathons in 94 days from St. Johns NFLD to his home town of Niagara Falls in honor of Matteo Mancini, a boy who was Mike's inspiration from his first Box Run, who lost his battle to cancer on May 8, 2013. Mike started this epic run, one year from Matteo's passing and continues to raise money for his new charity, named the Box Run charitable Foundation for childhood cancer research.

Working with Michael DiCienzo, Victor Pietrangelo and John Ventresca, Mike and the rest of the team came up with the idea of Box Climb. All four men will be climbing Matterhorn, which is located on the border of Italy and Switzerland. The Matterhorn is one of the highest peaks in the Alps and Europe, measuring 4,478 meters in elevation. Sometimes referred to as the Mountain of Mountains, the Matterhorn has become an iconic emblem of the Alps. Team Box Climb will be scaling the Matterhorn to conquer childhood cancer. Box Climb is fundraising for the Ronald McDonald House Charities of Southwestern Ontario.